Research Studies

Renal Disease Research Institute (RDRI) is a research entity affiliated with Dallas Nephrology Associates. For more than 50 years, Dallas Nephrology Associates has been caring for patients with kidney disease, hypertension, transplants and complicated electrolyte disorders. The Research Institute allows us to conduct clinical trials that will improve our future ability to treat kidney disease and give our patients the opportunity to receive cutting-edge therapy.  At RDRI, there is significant ethical oversight of this entity through RDRI’s Board of Managers and Scientific Review Committee.

Choosing to participate in a study is an important personal decision. Are you interested in participating in a study?  Talk with your doctor and family members or friends about deciding to join a study.

Protocol Name: A multicenter, randomized, double-blind, parallel-group, placebo-controlled study to assess the efficacy, safety, tolerability, pharmacokinetics and pharmacodynamics profile of BI 764198 administered orally once daily for 12 weeks in patients with focal segmental glomerulosclerosis. (BI FSGS)

Indication: Treatment of focal segmental glomerulosclerosis

PI: Dr. Anupkumar Shetty

Location: Charlton office - 2651 Bolton Boone Desoto, TX 75115

Protocol Name: A pivotal Phase 3, multicenter, randomized, double-blind, placebo-controlled study of the efficacy and safety of DMX-200 in patients with focal segmental glomerulosclerosis (FSGS) who are receiving an angiotensin II receptor blocker (Action3)

Indication: Focal segmental glomerulosclerosis (FSGS)

PI: Dr. Kim Rice

Location: 411 N Washington Ave, Suite 6000, Dallas, TX 75204

Protocol Name: A multi-center, randomized, double-blind, placebo-controlled, parallel-group, phase III study to evaluate the efficacy and safety of LNP023 in primary IgA nephropathy patients (Applause)

Indication: Treatment of Primary IgA nephropathy Patients

PI: Dr. Anupkumar Shetty

Location: Charlton office- 2651 Bolton Boone Desoto, TX 75115

Protocol Name: A Prospective, Multi-Center Clinical Study of the BD® WavelinQ™ EndoAVF System for the Creation of Arteriovenous (AV) Fistula in Patients Requiring Dialysis (BARD)

Indication: Patients requiring dialysis, needing creation of AV fistula

PI: Dr. Neghae Mawla, MD

Location: 4401 Tradition Trail Plano, Texas 75093

Protocol Name: Effects of ziltivekimab versus placebo on cardiovascular outcomes in participants with established atherosclerotic cardiovascular disease, chronic kidney disease and systemic inflammation (Novo-Nordisk ZEUS Study)

Indication: Atherosclerotic cardiovascular disease, chronic kidney disease and systemic inflammation 

Primary Investigator:
Dr. Ankit Mehta

Location: 3604 Live Oak St. Suite 100, Dallas, Texas, 75204

Protocol Name: Prospective, Randomized, Controlled, Multicenter Study Comparing the Merit WRAPSODYTM Endovascular Stent Graft to Percutaneous Transluminal Angioplasty for Treatment of Venous Outflow Circuit Stenosis or Occlusion in Hemodialysis Patients (Merit Wave Study)

Indication: Treatment of Venous Outflow Circuit Stenosis or Occlusion in Hemodialysis Patients

Primary Investigators:
Dr. Neghae Mawla, MD 
Dr. Jeffrey Siegel, MD

Location: 3604 Live Oak St. Suite 100, Dallas, Texas, 75204

Protocol Name: A Phase 2, Open-Label, Basket Study of Atrasentan in Patients with Proteinuric Glomerular Diseases (The AFFINITY Study)

Indication: Proteinuric Glomerular Disease – IgAN, FSGS, Alport Syndrome, Diabetic Kidney disease

Primary Investigator: Dr. Akinwande Akinfolarin

Location: 411 N Washington Ave, Suite 6000, Dallas, TX 75204

Protocol Name: A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Atrasentan in Patients with IgA Nephropathy at Risk of Progressive Loss of Renal Function (The ALIGN Study)

Indication: Patients with IgA Nephropathy at Risk of Progressive loss of renal function

Primary Investigator: Dr. Akinwande Akinfolarin

Location: 411 N Washington Ave, Suite 6000, Dallas, TX 75204

Protocol Name: Expanded Access Treatment with Open-Label Pegunigalsidase Alfa for Fabry Patients (Fabry)(New)

Primary Investigator: Dr. Ankit Mehta

Indication: Treatment for Patients with Fabry Disease

Location: 3604 Live Oak St. Suite 100, Dallas, Texas, 75204

Protocol Name: A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of the Safety and Efficacy of OMS721 in Patients with Immunoglobulin A (IgA) Nephropathy (ARTEMIS-IGAN). (Omeros)

Indication: Immunoglobin nephropathy – IgA

PI: Dr. Akinwande Akinfolarin

Location: 411 N Washington Ave, Suite 6000, Dallas, TX 75204

Protocol Name: Clinical study protocol a pivotal phase 3 trial to evaluate the safety and efficacy of clazakizumab for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients (Imagine)

Indication: Chronic active antibody-mediated rejection in kidney transplant recipients

PI: Dr. Bernard Fischbach

Location: 3604 Live Oak St. Suite 100, Dallas, Texas, 75204

Clinical research studies are necessary to prove that a medicine or treatment is both safe and effective.